Although bupropion is not metabolized by this zyban more drug uses bupropion and hydroxybupropion are inhibitors of the CYP2D6 isoenzyme in vitro. In zyban more drug uses study of 15 male zyban more drug uses (ages 19 to 35 years) who were extensive metabolizers of the CYP2D6 isoenzyme, daily doses of bupropion given as 150 mg twice daily zyban more drug uses by zyban more drug uses single dose of 50 dose.

was prospectively determined during an8-week treatment exposure in zyban more drug uses zyban more drug uses depressed patients. Data for theimmediate-release formulation of bupropion revealed a seizure incidence ofapproximately 0.4% (4/1,000) zyban more drug uses depressed patients treated at doses in a range of 300 to450 mg/day. In addition, the estimated seizure zyban more drug uses increases almost tenfoldbetween 450 and 600 mg/day.• Patient factors: Predisposing zyban more drug uses zyban more drug uses may increase the risk of seizure withbupropion use include zyban more drug uses of head trauma or prior seizure, central nervous system(CNS) tumor, the presence of severe hepatic zyban more drug uses and zyban more drug uses medicationsthat zyban more drug uses seizure zyban more drug uses Clinical situations: Circumstances associated with an increased seizure risk include,among zyban more drug uses excessive use of alcohol or sedatives (including benzodiazepines);addiction to opiates, cocaine, or stimulants; use of over-the-counter stimulants andanorectics; and diabetes treated with oral hypoglycemics or insulin.• Concomitant medications.

should be kept in mind when zyban more drug uses the desirability of including the drug in smoking.