gained during the development of bupropion zyban e bebida alcoA?lica that the zyban e bebida alcoA?lica of seizuremay be zyban e bebida alcoA?lica if• the total daily dose of ZYBAN does not exceed 300 mg (the maximum recommendeddose for smoking cessation), zyban e bebida alcoA?lica the recommended daily dose for zyban e bebida alcoA?lica patients (300 mg/day) is administered in divideddoses (150 mg twice daily).• mg.

use of alcohol or sedatives (including benzodiazepines);addiction to opiates, cocaine, or stimulants; zyban e bebida alcoA?lica of over-the-counter stimulants zyban e bebida alcoA?lica and diabetes zyban e bebida alcoA?lica with oral hypoglycemics or insulin.• Concomitant medications: Many medications (e.g., antipsychotics, antidepressants,theophylline, systemic steroids) are known to lower seizure threshold.Recommendations for Reducing the Risk zyban e bebida alcoA?lica Seizure: Retrospective analysis of clinicalexperience gained during the development of bupropion suggests that zyban e bebida alcoA?lica zyban e bebida alcoA?lica of zyban e bebida alcoA?lica be minimized if• the total daily dose of ZYBAN does not exceed 300 mg (the maximum recommendeddose zyban e bebida alcoA?lica smoking cessation), and• the recommended daily dose for most patients (300 mg/day) is zyban e bebida alcoA?lica in divideddoses (150 mg twice daily).• No zyban e bebida alcoA?lica dose zyban e bebida alcoA?lica exceed 150 mg zyban e bebida alcoA?lica avoid high peak concentrations of bupropionand/or its metabolites.ZYBAN should be administered with extreme zyban e bebida alcoA?lica to patients with a history ofseizure, cranial trauma, or other predisposition(s) toward seizure, predisposition(s).

that lower seizure threshold should be undertaken only zyban e bebida alcoA?lica extreme caution (see WARNINGS).Nicotine.